Chemical and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English.
The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Sumio Ohtsuki
Faculty of Life Sciences, Kumamoto University
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28,233 registered articles
(updated on March 28, 2024)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
1.7
2022 Journal Impact Factor (JIF)
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Featured article
Volume 72 (2024) Issue 2 Pages 226-233
Development of a Water Soluble Self-assembling Analogue of Vizantin Read more
Editor's pick

Vizantin is a TLR-4 antagonist developed in the author's laboratory. In this article, to improve the water solubility of vizantin, the authors designed a new vizantin derivative in which all hydroxyl groups of the sugar unit were sulfated. It has been confirmed that the synthesized vizantin derivative spontaneously forms string-like micelles and dissolves in water. The authors also report that string-like micelles of more uniform size are formed in physiological saline than in distilled water, making it possible to prepare an ideal injection solution.

Volume 72 (2024) Issue 2 Pages 213-219
Nucleophilic Deprotection of p-Methoxybenzyl Ethers Using Heterogeneous Oxovanadium Catalyst Read more
Editor's pick

Heterogeneous catalysis has gained increasing interest in the growing demand of sustainable manufacturing of pharmaceutically relevant compounds. The authors report herein a mesoporous silica-supported oxovanadium (V-MPS4)-catalyzed nucleophilic removal of the p-methoxybenzyl (PMB) protective group on alcohols under mild and redox-neutral conditions. The method has a wide reaction scope, including primary, secondary, and tertiary alcohols with various functional groups. The catalyst was reused six times without a significant loss in the conversion. The advantages of using the heterogeneous catalyst were further demonstrated by conducting the deprotection reaction in a flow process, which showed significantly higher turnover frequency compared to the batch reactions.

Volume 72 (2024) Issue 2 Pages 200-208
Antiproliferative Activities of Cynaropicrin and Related Compounds against Cancer Stem Cells Read more
Editor's pick

The guaianolide sesquiterpene lactone cynaropicrin and its derivatives showed antiproliferative activity against human glioblastoma U-251 MG cells and their cancer stem cells. Accordingly, the authors synthesized several derivatives of cynaropicrin and investigated their structure-activity relationships. The authors conclude that the α-methylene-γ-butyrolactone moiety involved in the Michael addition reaction and the 5,7,5-ring are both important for antiproliferative activities. The results of this study suggest guaianolide sesquiterpene lactones are useful for developing anticancer drugs targeting glioblastoma.

Volume 72 (2024) Issue 2 Pages 234-239
8-Iodoisoquinolinone, a Conformationally Rigid Highly Reactive 2-Iodobenzamide Catalyst for the Oxidation of Alcohols by Hypervalent Iodine Read more
Editor's pick

[Highlighted Paper selected by Editor-in-Chief]
Catalytic hypervalent iodine oxidation reactions have recently attracted attention to as an environmentally benign and safe method. The authors now report the first lactam-type 2-iodobenzamide catalysts, 8-iodoisoquinolinones (IB-lactams), that can act as a catalyst at room temperature for the oxidation of alcohols with Oxone (2KHSO5·KHSO4·K2SO4) and show the highest reactivity among their previously reported ones. They have a conformationally rigid 6/6 bicyclic lactam structure. The lactam structure could form an efficient intramolecular I---O interaction in its hypervalent species. The interaction could stabilize them to achieve rapid oxidation to pentavalent iodine species, which can oxidize alcohols to carbonyl compounds.

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