JBCS

Optimization of the Extraction Process of Bioactive Compounds from Zingiber officinale Roscoe, Evaluation of Acetylcholinesterase Enzyme Inhibition and Cytotoxic Activity of the Free and Encapsulated Extract

Danielli A. Nardino; Ana C. R. Aranha ; Lilian T. D. Tonin; Rafael O. Defendi; Sabrina Ishikawa; Patricia A. Bressiani; Ana B. S. Santana; Elisângela Dusman; Murilo K. A. Yonekawa; Jeandre A. S. Jaques; Edson A. Santos; Angélica P. P. Tonin;
Eduardo C. Meurer ; Caroline C. Sipoli; Rúbia M. Suzuki

Optimization of the extraction  process of   bioactive compounds present in ginger (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic      acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH) and chelating activity of Fe^II) followed by the characterization of the extraction, evaluation of cytotoxic activity and production of liposomes.

https://dx.doi.org/10.21577/0103-5053.20230186

Mercury Extraction from Multivitamin Mixtures Followed by Determination Using FI-CV-ICP-MS

Ana B. Viana; Cristiane Pappis; Viviane L. Garcia; Dylan M. Hoffmann; Arthur F. Burg; Valderi L. Dressler

Vitamin and nutrient supplements have been increasingly consumed. However, these supplements may be contaminated with toxic elements such as mercury.

https://dx.doi.org/10.21577/0103-5053.20230187

Ionic Liquid-Catalyzed Multicomponent Synthesis of Isoxazole-5(4H)-ones: in vitro Activities and Principal Component Analysis

Yasmine B. Queiroz; Yasmin A. de Freitas; Juliana G. M. Lima; Luciano Ribeiro; Luciana M. Ramos

The multicomponent synthesis of isoxazol-5(4H)-ones using an imidazolium-type ionic liquid catalyst provided varying product yields under mild reaction conditions. Through principal component analysis (PCA), a weighted graph was generated representing the descriptors that influence the antimicrobial activity of the derivatives.

https://dx.doi.org/10.21577/0103-5053.20230188

Chemical Profile of Drug Infused Papers Seized in Rio de Janeiro (Brazil) Prisons During the COVID-19 Lockdown

Adriana S. de Oliveira; Ananda S. Antonio ; Cecília A. Bhering; Gleicielle T. Wurzler; Fernando G. de Almeida; Diego R. Carvalhosa; Marco Antônio M. de Oliveira; Francisco R. de Aquino Neto; Gabriela V. Costa

Despite coronavirus disease (COVID-19) closure of boards, trafficking of novel synthetic cannabinoids was still present, even inside prison facilities. During COVID-19 lockdown three synthetic cannabinoids were reported for the first time in Rio de Janeiro.

https://dx.doi.org/10.21577/0103-5053.20230189

Extraction Method for Determining Dinotefuran Insecticide in Soil Samples

Sandro B. Soares; Lázaro C. Sicupira; Gevany P. de Pinho; Flaviano O. Silvério

This study optimized and validated for the first time the solid-liquid extraction with low temperature purification (SLE-LTP) method to determine dinotefuran insecticide residues in soil samples.

https://dx.doi.org/10.21577/0103-5053.20230190

Electrochemical Investigations of Protein Denaturating Agents Dithiobutylamine and Dithiothreitol and of the Antineoplastic Alemtuzumab at Glassy Carbon Electrode

Nathalia L. Queiroz; Maycom W. F. Silva; Maysa L. Nascimento; José G. da Silva Neto; José Ailton M. Nascimento; Katia C. S. Freitas; Eric S. Gil ; Severino Carlos B. Oliveira

A study to establish redox and thermodynamic properties of the protein denaturing agents dithiobutylamine and dithiothreitol was carried out on a glassy carbon electrode.

https://dx.doi.org/10.21577/0103-5053.20230191

NMR and Chemometrics in the Determination of Chemical Profiles for the Distinction of Brazilian Ale and Lager Beers

Lázaro S. de Jesus ; Igor S. Flores ; Vinícius S. Pinto ; Gislane O. Ribeiro ; Karla C. R. C. Morais ; Luciano M. Lião

Nuclear magnetic resonance (NMR) and chemometrics determined the chemical profiles of different styles of beer. Ale and lager beers are differentiated.

https://dx.doi.org/10.21577/0103-5053.20230192

Semisynthesis and Cytotoxic Activities of Novel Oxime Ester Derivatives of the Diterpene Stemodin

José Augusto C. de Oliveira; Carlos José Alves Filho; Antônio Marcelo A. Lima; Cláudia do Ó Pessoa; Fátima de Cássia E. de Oliveira; Fátima N. Miranda; Marcos Carlos de Mattos ; Maria Conceição F. Oliveira ; Jair Mafezoli ; Francisco Geraldo Barbosa

New semisynthetic derivatives obtained from the diterpene stemodin, isolated from Stemodia maritima, and evaluation of the cytotoxic activity.

https://dx.doi.org/10.21577/0103-5053.20230193

In situ Transesterification of Crambe Seeds with Dimethyl Carbonate Using an Enzymatic Catalyst

Camila da Silva ; Thainara B. Massa ; Bruna Tais F. de Mello ; Mirian Cristina Feiten ; Natália Stevanato ; Najla Postaue

In situ production of methyl esters from crambe seeds applying dimethyl carbonate, as extraction solvent and acyl acceptor, and enzymatic catalyst.

https://dx.doi.org/10.21577/0103-5053.20230194

Computational Insight and Anticancer Effect of Cinnamic Acid-Derivative Amide Compounds

Aldo Y. Alarcón-López ; Manuel A. Hernández-Serda ; Pablo Aguirre-Vidal; Luis A. Cárdenas-Granados ; Víctor H. Vázquez-Valadez; Pablo A. Martínez‑Soriano; Paola Briseño-Lugo; Ana M. Velázquez-Sánchez; Elizabeth Rul-Ramírez; María Luisa Jiménez-Jiménez; Jared Becerril-Ricco; Alhel Adán-Ladrón de Guevara; José Manuel Tinajero-Rodríguez; Elizabeth Ortiz; Enrique Ángeles

This study investigates a series of compounds analogous to caffeic acid phenethyl ester, designed in-house, with promising potential as anticancer agents.

https://dx.doi.org/10.21577/0103-5053.20230195

Pd-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction in Glycerol Using KOH as Base and Glycerol-Triethanolamine Deep Eutectic Solvent under Inorganic Base‑Free Conditions

Adriano L. Monteiro ; Zahid Hussain; Tatiana Z. N. Eichler; Bárbara C. Leal

Glycerol-triethanolamine deep eutectic solvent allows the cross-coupling reaction to proceed under inorganic base-free conditions. Triethanolamine phenylboronates were formed in situ and cross-coupling products can be easily extracted with hexane.

https://dx.doi.org/10.21577/0103-5053.20230197

Study of the Stability and Homogeneity of Powdered Egg Matrix as a Candidate for Certified Reference Material for the Determination of Centesimal Composition

Tiago Antonio M. Lopes; Lucas Ulisses R. Chiavelli; Patrícia Daniele S. dos Santos; Jesuí V. Visentainer; Oscar O. Santos

Development of a Certified Reference Material (CRM) candidate in powdered egg matrix that meets the production minimum requirements to become a reference material, evaluating its homogeneity and stability, for application in physical-chemical analysis of total solids, fixed mineral residue and protein.

https://dx.doi.org/10.21577/0103-5053.20230199

Enhanced Detection of Benzo[a]pyrene in Olive Oil through Low Temperature Liquid-Liquid Extraction Coupled with Constant Energy Synchronous Fluorescence Spectroscopy

Willian M. Soares ; Ricardo M. Orlando ; Helvécio C. Menezes

Schematic representation of the incidence of benzo[a]pyrene in olive oil and the employed method to determine its presence and concentration.

https://dx.doi.org/10.21577/0103-5053.20230200

Indium Recovery from End-of-Life E-Waste: Important Details Related to Spectroanalytical Determination and Recycling Viability

Jeyne Pricylla Castro; José Augusto Garcia; Ricardo G. Souza; Edenir R. Pereira-Filho

Indium from waste electrical and electronic equipment (WEEE) determination and recycling proposition.

https://dx.doi.org/10.21577/0103-5053.20230201

In silico and in vitro Studies Evaluating the Promising Antiureolytic Activity of Schiff's Base 4-(3-Hydroxybenzylideneamino)phenol and Its Amine Derivative

Caroline S. Dohanik; Camila P. Pereira; Breno G. F. de Oliveira; Igor J. S. Nascimento; Amanda Luise A. Nascimento;
Josué C. C. Santos ; Thiago M. de Aquino; Rachel O. Castilho; Luzia V. Modolo ; Ângelo de Fátima ; Gisele A. C. Goulart

Study of anti-ureolytic activity and the interaction of the Schiff base 4-(3-hydroxybenzylideneamino) phenol (3B4) and its amine derived (3B4a) against urease.

https://dx.doi.org/10.21577/0103-5053.20240001

Magnetic Crosslinked Porcine Pancreatic Lipase Aggregates for Transesterification Process

Caroline O. da Rocha ; Rodolfo D. Piazza; Caio C. dos Santos; Guilherme N. Lucena; Bruno E. Amantea; Miguel Jafelicci Jr. ;
Ariela V. de Paula; Anselmo F. Ruiz Rodriguez ; Marco Antonio Morales; Rodrigo Fernando C. Marques

Magnetic crosslinked enzyme aggregates finding application on olive oil transesterification. It may be magnetically separated and reused for 6 cycles.

https://dx.doi.org/10.21577/0103-5053.20240002

Versatile Applications of Cyanoacetic Acid in Organic Chemistry: Active Methylene Compound for the Knoevenagel Condensation and Organocatalyst for the Biginelli Reaction

Lucas L. Zanin; David E. Q. Jimenez; Gabriel D. S. Baia; Victor H. Marinho; Inana F. de Araujo; Ryan D. S. Ramos; Raimundo N. Soto; Irlon M. Ferreira ; Pedro H. O. Santiago; Javier Ellena ; André L. M. Porto

An efficient and green methodology for the use of cyanoacetic acid as active methylene group to aldol type condensation reaction and catalyst for Biginelli reaction was investigated in this study.

https://dx.doi.org/10.21577/0103-5053.20240003

https://dx.doi.org/10.21577/0103-5053.20240012